| Ranking | University | Nation |
| 1 | Massachusetts Institute of Technology | United States |
| 2 | stanford University | United States |
| 3 | Harvard University | United States |
| 4 | California Institute of Technology | United States |
| 5 | University of Oxford | United Kingdom |
| 6 | ETH Zurich | Switzerland |
| 7 | University of Cambridge | United Kingdom |
| 8 | Imperial College London | United Kingdom |
| 9 | University of Chicago | United States |
| 10 | UCL | United Kingdom |
| 11 | National University of Singapore | Singapore |
| 12 | Princeton University | United States |
| 13 | Nanyang Technological University | Singapore |
| 14 | EPFL | Switzerland |
| 15 | Tsinghua University | China |
| 16 | University of Pennsylvania | United States |
| 17 | Yale University | United States |
| 18 | Cornell University | United States |
| 19 | Columbia University | United States |
| 20 | The University of Edinburgh | United Kingdom |
| 21 | University of Michigan-Ann Arbor | United States |
| 22 | The University of Hong Kong | Hong Kong |
| 23 | Peking University | China |
| 24 | The University of Tokyo | Japan |
| 25 | Johns Hopkins University | United States |
| 26 | University of Toronto | Canada |
| 27 | The Hong Kong University of Science and Technology | Hong Kong |
| 28 | The University of Manchester | United Kingdom |
| 29 | Northwestern University | United States |
| 30 | The University of California, Berkeley | United States |
| 31 | The Australian National University | Australia |
| 32 | King's College London | United Kingdom |
| 33 | McGill University | Canada |
| 34 | Fudan University | China |
| 35 | New York University | United States |
| 36 | UCLA | United States |
| 37 | Seoul National University | South Korea |
| 38 | Kyoto University | Japan |
| 39 | KAIST | South Korea |
| 40 | The University of Sydney | Australia |
| 41 | The University of Melbourne | Australia |
| 42 | Duke University | United States |
| 43 | The Chinese University of Hong Kong | Hong Kong |
| 44 | UNSW Sydney | Australia |
| 45 | University of British Columbia | Canada |
| 46 | The University of Queensland | Australia |
| 47 | Shanghai Jiao Tong University | China |
| 48 | City University of Hong Kong | Hong Kong |
| 49 | LSE | United Kingdom |
| 50 | Technical University of Munich | Germany |
來源: QS University Rankings 2021
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